Currently, bacterial sequencing has a profound impact on the field of genomics. Based on the short gun sequencing approach the sequences of Leptospirilum, H.influenza is available on biological databases. This deals with hereditary information about bacteria, theta replication, transcription Genome information assists in Linkage mapping and genetic mapping. Genomics of Bacteria also includes phenomenon like Pleiotropy, epistasis. Colonization of bacteria is based on Virulence factors, currently, genome editing tools like CRISPR/Cas were available for genome sequencing of bacteria.